Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO).
Identifieur interne : 000062 ( Main/Exploration ); précédent : 000061; suivant : 000063Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO).
Auteurs : B. Hermann [Allemagne] ; N. Lehners [Allemagne] ; M. Brodhun [Allemagne] ; K. Boden [Allemagne] ; A. Hochhaus [Allemagne] ; M. Kochanek [Allemagne] ; K. Meckel [Allemagne] ; K. Mayer [Allemagne] ; T. Rachow [Allemagne] ; C. Rieger [Allemagne] ; E. Schalk [Allemagne] ; T. Weber [Allemagne] ; A. Schmeier-Jürchott [Allemagne] ; P. Schlattmann [Allemagne] ; D. Teschner [Allemagne] ; M. Von Lilienfeld-Toal [Allemagne]Source :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [ 1435-4373 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Allemagne (épidémiologie), Analyse de survie (MeSH), Antiviraux (usage thérapeutique), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (anatomopathologie), Grippe humaine (mortalité), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Mâle (MeSH), Oséltamivir (usage thérapeutique), Résultat thérapeutique (MeSH), Sociétés (MeSH), Soins de réanimation (MeSH), Sujet âgé (MeSH), Surinfection (épidémiologie), Tumeurs (complications), Virus de la grippe A (isolement et purification), Virus influenza B (isolement et purification).
- MESH :
- anatomopathologie : Grippe humaine.
- isolement et purification : Virus de la grippe A, Virus influenza B.
- mortalité : Grippe humaine.
- usage thérapeutique : Antiviraux, Oséltamivir, Tumeurs.
- virologie : Grippe humaine.
- épidémiologie : Allemagne, Grippe humaine, Surinfection.
- Adulte d'âge moyen, Analyse de survie, Facteurs de risque, Femelle, Humains, Mâle, Résultat thérapeutique, Sociétés, Soins de réanimation, Sujet âgé.
English descriptors
- KwdEn :
- Aged (MeSH), Antiviral Agents (therapeutic use), Critical Care (MeSH), Female (MeSH), Germany (epidemiology), Humans (MeSH), Influenza A virus (isolation & purification), Influenza B virus (isolation & purification), Influenza, Human (epidemiology), Influenza, Human (mortality), Influenza, Human (pathology), Influenza, Human (virology), Male (MeSH), Middle Aged (MeSH), Neoplasms (complications), Oseltamivir (therapeutic use), Risk Factors (MeSH), Societies (MeSH), Superinfection (epidemiology), Survival Analysis (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- complications : Neoplasms.
- epidemiology : Germany, Influenza, Human, Superinfection.
- isolation & purification : Influenza A virus, Influenza B virus.
- mortality : Influenza, Human.
- pathology : Influenza, Human.
- virology : Influenza, Human.
- Aged, Critical Care, Female, Humans, Male, Middle Aged, Risk Factors, Societies, Survival Analysis, Treatment Outcome.
Abstract
Influenza virus infections (IVI) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. In this study, we collected data on patients with active cancer or with a history of cancer, presenting with documented IVI in eight centres in Germany. Two hundred and three patients were identified, suffering from haematological malignancies or solid tumours; 109 (54 %) patients had active malignant disease. Influenza A was detected in 155 (77 %) and Influenza B in 46 (23 %) of patients (genera not determined in two patients). Clinical symptoms were consistent with upper respiratory tract infection in 55/203 (27 %), influenza-like illness in 82/203 (40 %), and pneumonia in 67/203 (33 %). Anti-viral treatment with oseltamivir was received by 116/195 (59 %). Superinfections occurred in 37/203 (18 %), and admission on an intensive care unit was required in 26/203 (13 %). Seventeen patients (9 %) died. Independent risk factors for death were delayed diagnosis of IVI and bacterial or fungal superinfection, but not underlying malignancy or ongoing immunosuppression. In conclusion, patients with IVI show high rates of pneumonia and mortality. Early and rapid diagnosis is essential. The high rate of pneumonia and superinfections should be taken into account when managing IVI in these patients.
DOI: 10.1007/s10096-016-2833-3
PubMed: 27838792
PubMed Central: PMC5309266
Affiliations:
- Allemagne
- Bade-Wurtemberg, Bavière, District de Cologne, District de Haute-Bavière, District de Karlsruhe, Rhénanie-Palatinat, Rhénanie-du-Nord-Westphalie, Saxe-Anhalt
- Bonn, Heidelberg, Magdebourg, Mayence, Munich
- Université Louis-et-Maximilien de Munich
Links toward previous steps (curation, corpus...)
Le document en format XML
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Hermann</name><affiliation wicri:level="1"><nlm:affiliation>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena, Germany. eckidtdf@mailbox.alumni.tu-berlin.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena</wicri:regionArea><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Lehners, N" sort="Lehners, N" uniqKey="Lehners N" first="N" last="Lehners">N. Lehners</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Brodhun, M" sort="Brodhun, M" uniqKey="Brodhun M" first="M" last="Brodhun">M. Brodhun</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Boden, K" sort="Boden, K" uniqKey="Boden K" first="K" last="Boden">K. Boden</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Klinische Chemie und Laboratoriumsmedizin, University Hospital Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Klinische Chemie und Laboratoriumsmedizin, University Hospital Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Kochanek, M" sort="Kochanek, M" uniqKey="Kochanek M" first="M" last="Kochanek">M. Kochanek</name><affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Meckel, K" sort="Meckel, K" uniqKey="Meckel K" first="K" last="Meckel">K. Meckel</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, K" sort="Mayer, K" uniqKey="Mayer K" first="K" last="Mayer">K. Mayer</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik III, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik III, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Rachow, T" sort="Rachow, T" uniqKey="Rachow T" first="T" last="Rachow">T. Rachow</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Rieger, C" sort="Rieger, C" uniqKey="Rieger C" first="C" last="Rieger">C. Rieger</name><affiliation wicri:level="4"><nlm:affiliation>Internistische Lehrpraxis der Ludwig-Maximilians-Universität München, University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Internistische Lehrpraxis der Ludwig-Maximilians-Universität München, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Schalk, E" sort="Schalk, E" uniqKey="Schalk E" first="E" last="Schalk">E. Schalk</name><affiliation wicri:level="3"><nlm:affiliation>Otto-von-Guericke University Magdeburg, Medical Centre, Department of Haematology and Oncology, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Otto-von-Guericke University Magdeburg, Medical Centre, Department of Haematology and Oncology, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Weber, T" sort="Weber, T" uniqKey="Weber T" first="T" last="Weber">T. Weber</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Halle, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Halle, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Schmeier Jurchott, A" sort="Schmeier Jurchott, A" uniqKey="Schmeier Jurchott A" first="A" last="Schmeier-Jürchott">A. Schmeier-Jürchott</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre of the Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Schlattmann, P" sort="Schlattmann, P" uniqKey="Schlattmann P" first="P" last="Schlattmann">P. Schlattmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Teschner, D" sort="Teschner, D" uniqKey="Teschner D" first="D" last="Teschner">D. Teschner</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre of the Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Von Lilienfeld Toal, M" sort="Von Lilienfeld Toal, M" uniqKey="Von Lilienfeld Toal M" first="M" last="Von Lilienfeld-Toal">M. Von Lilienfeld-Toal</name><affiliation wicri:level="1"><nlm:affiliation>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena</wicri:regionArea><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forschungscampus InfectoGnostics, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Forschungscampus InfectoGnostics, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Integriertes Forschungs- und Behandlungszentrum Sepsis und Sepsisfolgen (CSCC), Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Integriertes Forschungs- und Behandlungszentrum Sepsis und Sepsisfolgen (CSCC), Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27838792</idno><idno type="pmid">27838792</idno><idno type="doi">10.1007/s10096-016-2833-3</idno><idno type="pmc">PMC5309266</idno><idno type="wicri:Area/Main/Corpus">000072</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000072</idno><idno type="wicri:Area/Main/Curation">000072</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000072</idno><idno type="wicri:Area/Main/Exploration">000072</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO).</title><author><name sortKey="Hermann, B" sort="Hermann, B" uniqKey="Hermann B" first="B" last="Hermann">B. Hermann</name><affiliation wicri:level="1"><nlm:affiliation>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena, Germany. eckidtdf@mailbox.alumni.tu-berlin.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena</wicri:regionArea><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Lehners, N" sort="Lehners, N" uniqKey="Lehners N" first="N" last="Lehners">N. Lehners</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Haematology and Oncology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Brodhun, M" sort="Brodhun, M" uniqKey="Brodhun M" first="M" last="Brodhun">M. Brodhun</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Boden, K" sort="Boden, K" uniqKey="Boden K" first="K" last="Boden">K. Boden</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Klinische Chemie und Laboratoriumsmedizin, University Hospital Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Klinische Chemie und Laboratoriumsmedizin, University Hospital Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Kochanek, M" sort="Kochanek, M" uniqKey="Kochanek M" first="M" last="Kochanek">M. Kochanek</name><affiliation wicri:level="1"><nlm:affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department I of Internal Medicine, University Hospital of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Meckel, K" sort="Meckel, K" uniqKey="Meckel K" first="K" last="Meckel">K. Meckel</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, K" sort="Mayer, K" uniqKey="Mayer K" first="K" last="Mayer">K. Mayer</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik III, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik III, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Rachow, T" sort="Rachow, T" uniqKey="Rachow T" first="T" last="Rachow">T. Rachow</name><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Rieger, C" sort="Rieger, C" uniqKey="Rieger C" first="C" last="Rieger">C. Rieger</name><affiliation wicri:level="4"><nlm:affiliation>Internistische Lehrpraxis der Ludwig-Maximilians-Universität München, University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Internistische Lehrpraxis der Ludwig-Maximilians-Universität München, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Schalk, E" sort="Schalk, E" uniqKey="Schalk E" first="E" last="Schalk">E. Schalk</name><affiliation wicri:level="3"><nlm:affiliation>Otto-von-Guericke University Magdeburg, Medical Centre, Department of Haematology and Oncology, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Otto-von-Guericke University Magdeburg, Medical Centre, Department of Haematology and Oncology, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Weber, T" sort="Weber, T" uniqKey="Weber T" first="T" last="Weber">T. Weber</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Halle, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Halle, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Schmeier Jurchott, A" sort="Schmeier Jurchott, A" uniqKey="Schmeier Jurchott A" first="A" last="Schmeier-Jürchott">A. Schmeier-Jürchott</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre of the Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Schlattmann, P" sort="Schlattmann, P" uniqKey="Schlattmann P" first="P" last="Schlattmann">P. Schlattmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Teschner, D" sort="Teschner, D" uniqKey="Teschner D" first="D" last="Teschner">D. Teschner</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre of the Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Von Lilienfeld Toal, M" sort="Von Lilienfeld Toal, M" uniqKey="Von Lilienfeld Toal M" first="M" last="Von Lilienfeld-Toal">M. Von Lilienfeld-Toal</name><affiliation wicri:level="1"><nlm:affiliation>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena</wicri:regionArea><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>07745 , Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forschungscampus InfectoGnostics, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Forschungscampus InfectoGnostics, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Integriertes Forschungs- und Behandlungszentrum Sepsis und Sepsisfolgen (CSCC), Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Integriertes Forschungs- und Behandlungszentrum Sepsis und Sepsisfolgen (CSCC), Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</title><idno type="eISSN">1435-4373</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Antiviral Agents (therapeutic use)</term><term>Critical Care (MeSH)</term><term>Female (MeSH)</term><term>Germany (epidemiology)</term><term>Humans (MeSH)</term><term>Influenza A virus (isolation & purification)</term><term>Influenza B virus (isolation & purification)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (mortality)</term><term>Influenza, Human (pathology)</term><term>Influenza, Human (virology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neoplasms (complications)</term><term>Oseltamivir (therapeutic use)</term><term>Risk Factors (MeSH)</term><term>Societies (MeSH)</term><term>Superinfection (epidemiology)</term><term>Survival Analysis (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (épidémiologie)</term><term>Analyse de survie (MeSH)</term><term>Antiviraux (usage thérapeutique)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (anatomopathologie)</term><term>Grippe humaine (mortalité)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Oséltamivir (usage thérapeutique)</term><term>Résultat thérapeutique (MeSH)</term><term>Sociétés (MeSH)</term><term>Soins de réanimation (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Surinfection (épidémiologie)</term><term>Tumeurs (complications)</term><term>Virus de la grippe A (isolement et purification)</term><term>Virus influenza B (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Germany</term><term>Influenza, Human</term><term>Superinfection</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Oséltamivir</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe humaine</term><term>Surinfection</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Critical Care</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Societies</term><term>Survival Analysis</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sociétés</term><term>Soins de réanimation</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza virus infections (IVI) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. In this study, we collected data on patients with active cancer or with a history of cancer, presenting with documented IVI in eight centres in Germany. Two hundred and three patients were identified, suffering from haematological malignancies or solid tumours; 109 (54 %) patients had active malignant disease. Influenza A was detected in 155 (77 %) and Influenza B in 46 (23 %) of patients (genera not determined in two patients). Clinical symptoms were consistent with upper respiratory tract infection in 55/203 (27 %), influenza-like illness in 82/203 (40 %), and pneumonia in 67/203 (33 %). Anti-viral treatment with oseltamivir was received by 116/195 (59 %). Superinfections occurred in 37/203 (18 %), and admission on an intensive care unit was required in 26/203 (13 %). Seventeen patients (9 %) died. Independent risk factors for death were delayed diagnosis of IVI and bacterial or fungal superinfection, but not underlying malignancy or ongoing immunosuppression. In conclusion, patients with IVI show high rates of pneumonia and mortality. Early and rapid diagnosis is essential. The high rate of pneumonia and superinfections should be taken into account when managing IVI in these patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27838792</PMID><DateCompleted><Year>2017</Year><Month>02</Month><Day>22</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1435-4373</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Mar</Month></PubDate></JournalIssue><Title>European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</Title><ISOAbbreviation>Eur. J. Clin. Microbiol. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO).</ArticleTitle><Pagination><MedlinePgn>565-573</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10096-016-2833-3</ELocationID><Abstract><AbstractText>Influenza virus infections (IVI) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. In this study, we collected data on patients with active cancer or with a history of cancer, presenting with documented IVI in eight centres in Germany. Two hundred and three patients were identified, suffering from haematological malignancies or solid tumours; 109 (54 %) patients had active malignant disease. Influenza A was detected in 155 (77 %) and Influenza B in 46 (23 %) of patients (genera not determined in two patients). Clinical symptoms were consistent with upper respiratory tract infection in 55/203 (27 %), influenza-like illness in 82/203 (40 %), and pneumonia in 67/203 (33 %). Anti-viral treatment with oseltamivir was received by 116/195 (59 %). Superinfections occurred in 37/203 (18 %), and admission on an intensive care unit was required in 26/203 (13 %). Seventeen patients (9 %) died. Independent risk factors for death were delayed diagnosis of IVI and bacterial or fungal superinfection, but not underlying malignancy or ongoing immunosuppression. In conclusion, patients with IVI show high rates of pneumonia and mortality. Early and rapid diagnosis is essential. The high rate of pneumonia and superinfections should be taken into account when managing IVI in these patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hermann</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena, Germany. eckidtdf@mailbox.alumni.tu-berlin.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehners</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Haematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brodhun</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boden</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institut für Klinische Chemie und Laboratoriumsmedizin, University Hospital Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hochhaus</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kochanek</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meckel</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayer</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medizinische Klinik III, University Hospital Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rachow</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rieger</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Internistische Lehrpraxis der Ludwig-Maximilians-Universität München, University of Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schalk</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Otto-von-Guericke University Magdeburg, Medical Centre, Department of Haematology and Oncology, Magdeburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weber</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>University Hospital Halle, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmeier-Jürchott</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlattmann</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medical Statistics, Informatics and Documentation, University Hospital Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teschner</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Lilienfeld-Toal</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans-Knöll-Institut, 07745 , Jena, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medizinische Klinik II, Abteilung für Haematologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Forschungscampus InfectoGnostics, Jena, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Integriertes Forschungs- und Behandlungszentrum Sepsis und Sepsisfolgen (CSCC), Universitätsklinikum Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Eur J Clin Microbiol Infect Dis</MedlineTA><NlmUniqueID>8804297</NlmUniqueID><ISSNLinking>0934-9723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):3434-3436</RefSource><PMID Version="1">32329810</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003422" MajorTopicYN="N">Critical Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012952" MajorTopicYN="N">Societies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015163" MajorTopicYN="N">Superinfection</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><CoiStatement>Compliance with ethical standardsFundingPartially funded by Infectognostics Forschungscampus, grant number BMBF 13GW0096D.Conflicts of interestMarie von Lilienfeld-Toal: honoraria, travel grant, and research grant from MSD and Celgene. Honoraria and travel grant from Gilead, Janssen Cilag, and Astellas. Consultant of advisory board for MSD.Daniel Teschner: honoraria and travel grant from Gilead and MSD. Travel grant from Astellas and Jazz. Consultant of advisory board for MSD and Pfizer.Andreas Hochhaus: research support from Novartis, BMS, Pfizer, AriadBeate Hermann: noneNicola Lehners: noneMaria Brodhun, Katharina Boden, Matthias Kochanek, Katharina Meckel, Karin Mayer, Tobias Rachow, Christina Rieger, Enrico Schalk, Thomas Weber, Anna Schmeier-Jürchott, Peter Schlattmann: noneEthical approvalThe study was approved by the ethics committee of Jena University Hospital (3785-05/13).Informed consentNo informed consent was required since this was a retrospective study.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>10</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Karlsruhe</li><li>Rhénanie-Palatinat</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe-Anhalt</li></region><settlement><li>Bonn</li><li>Heidelberg</li><li>Magdebourg</li><li>Mayence</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Hermann, B" sort="Hermann, B" uniqKey="Hermann B" first="B" last="Hermann">B. Hermann</name></noRegion><name sortKey="Boden, K" sort="Boden, K" uniqKey="Boden K" first="K" last="Boden">K. Boden</name><name sortKey="Brodhun, M" sort="Brodhun, M" uniqKey="Brodhun M" first="M" last="Brodhun">M. Brodhun</name><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><name sortKey="Kochanek, M" sort="Kochanek, M" uniqKey="Kochanek M" first="M" last="Kochanek">M. Kochanek</name><name sortKey="Lehners, N" sort="Lehners, N" uniqKey="Lehners N" first="N" last="Lehners">N. Lehners</name><name sortKey="Mayer, K" sort="Mayer, K" uniqKey="Mayer K" first="K" last="Mayer">K. Mayer</name><name sortKey="Meckel, K" sort="Meckel, K" uniqKey="Meckel K" first="K" last="Meckel">K. Meckel</name><name sortKey="Rachow, T" sort="Rachow, T" uniqKey="Rachow T" first="T" last="Rachow">T. Rachow</name><name sortKey="Rieger, C" sort="Rieger, C" uniqKey="Rieger C" first="C" last="Rieger">C. Rieger</name><name sortKey="Schalk, E" sort="Schalk, E" uniqKey="Schalk E" first="E" last="Schalk">E. Schalk</name><name sortKey="Schlattmann, P" sort="Schlattmann, P" uniqKey="Schlattmann P" first="P" last="Schlattmann">P. Schlattmann</name><name sortKey="Schmeier Jurchott, A" sort="Schmeier Jurchott, A" uniqKey="Schmeier Jurchott A" first="A" last="Schmeier-Jürchott">A. Schmeier-Jürchott</name><name sortKey="Teschner, D" sort="Teschner, D" uniqKey="Teschner D" first="D" last="Teschner">D. Teschner</name><name sortKey="Von Lilienfeld Toal, M" sort="Von Lilienfeld Toal, M" uniqKey="Von Lilienfeld Toal M" first="M" last="Von Lilienfeld-Toal">M. Von Lilienfeld-Toal</name><name sortKey="Von Lilienfeld Toal, M" sort="Von Lilienfeld Toal, M" uniqKey="Von Lilienfeld Toal M" first="M" last="Von Lilienfeld-Toal">M. Von Lilienfeld-Toal</name><name sortKey="Von Lilienfeld Toal, M" sort="Von Lilienfeld Toal, M" uniqKey="Von Lilienfeld Toal M" first="M" last="Von Lilienfeld-Toal">M. Von Lilienfeld-Toal</name><name sortKey="Von Lilienfeld Toal, M" sort="Von Lilienfeld Toal, M" uniqKey="Von Lilienfeld Toal M" first="M" last="Von Lilienfeld-Toal">M. Von Lilienfeld-Toal</name><name sortKey="Weber, T" sort="Weber, T" uniqKey="Weber T" first="T" last="Weber">T. Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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